2-(4-PYRIDYL)-6-NITRO-7-OXO-4,7-DIHYDRO-1,2,4-TRIAZOLO [5,1-C][1,2,4]TRIAZINE AMMONIUM SALT SHOWING ANTIVIRAL ACTIVITY Russian patent published in 1994 - IPC

Abstract SU 1473303 A1

FIELD: heterocyclic compounds. SUBSTANCE: product: ammonium salt of 2-(4-pyridyl)-6-nitro-7-oxo-4,7-dihydro-1, 2,4-triazolo[5,1-c][1,2,4]triazine. Synthesis is carried out by reaction of 3- (4-pyridyl)-5-diazo-1,2,4-triazole prepared by diazotization of 3-(4-pyridyl)- -5-amino-1,2,4-triazole with nitroacetic acid ethyl ester in aqueous-spirituous solution of ammonium hydrocarbonate. Yield is 60%, m.p. is above 300 C, gross-formula is C₉H₈N₈O₃. New compound inhibits reproduction of Rift Valley fever virus in infected cultures of cells by 2 lg PFU/0.1 ml and protects white mice (by 80% ) against development of this infection (100% death of animal in control). Synthesized compound display antiviral activity. EFFECT: synthesis of new compound of class indicated above showing new kind of activity. 2 tbl

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SU 1 473 303 A1

Authors

Chupakhin O.N.

Rusinov V.L.

Ulomskij E.N.

L'Vov D.K.

Berezina L.K.

Dates

1994-06-15—Published

1987-08-17—Filed