FIELD: chemistry, particularly, pharmacology; manufacture of antiinflammatory, antipyretic and analgetic drugs. SUBSTANCE: desired product: N-2(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide. Melting point: 199 to 201 C. Yield: 75 to 80 %. Reagent No. 1: ethyl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide. Reagent No. 2: 2-aminopyridine. Reaction conditions: xylene medium with boiling in presence of anhydrous calcium chloride. Molar ratio between anhydrous calcium chloride and reagent No. 1 is 1 : 0.5 to 1.0. EFFECT: excellent antiinflammatory, antipyretic and analgetic medicine. 1 cl
| Title |
Year |
Author |
Number |
| METHOD OF PRODUCING N-(2-PYRIDYL)-2-METHYL-4-OXY-2H-BENZOTHIAZINE-3-CARBOXAMIDE-1,1-DIOXIDE |
0 |
- Natasha Zupanchich
- Boris Shket
- Pavel Zupet
- Marko Zupan
|
SU1322982A3 |
| METHOD OF PRODUCING 2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-1,1-DIOXIDE-3-N-(2-PYRIDYL)-CARBOXAMIDE |
0 |
- Pekka Yukhani Kajrisalo
- Erkki Yukhani Khonkanen
- Magnus Evard Valdemar Jokhansson
- Matti Karkhu
- Pentti Tapio Nore
- Ajno Killikki Pippuri
- Irma Ritva Khelena Kurimo
|
SU1405703A3 |
| METHOD FOR PRODUCING 2-METHYL-3-N-(2-PYRIDYL)-CARBAMOYL-3,4-DIHYDRO-2H-1,2-BENZTHIAZINE-1,1-DIOXIDE |
0 |
|
SU1306476A3 |
| METHOD OF SYNTHESIS OF 3-ALKOXYCARBONYL-4-HYDROXY-2-METHYL-2H- -1,2-BENZOTHIAZINE-1,1-DIOXIDES |
1993 |
- Medvedeva A.S.
- Podskrebyshev A.I.
- Safronova L.P.
- Voronkov M.G.
- Zaks A.S.
|
RU2109738C1 |
| METHOD OF OBTAINING BENZOTHIAZINE |
0 |
- Dzhozef Dzhordzh Lombardino
|
SU676164A3 |
| METHOD OF PREPARING 4-OXY-2H-NAPHTO 2,1-E1,2-THIAZINE-3-CARBOXAMIDE-1,1-DIOXIDES OR SALTS THEREOF |
0 |
- Gyunter Trummlitts
- Gelmut Tojfel
- Volfkhard Engel
- Ernst Zeeger
- Valter Khaarmann
- Gyunter Engelkhardt
|
SU575027A3 |
| METHOD OF PRODUCING CRYSTALLINE FORM OF MONOETHANOLAMINE SALT OF N-(2-PYRIDYL)-2-METHYL-4-OXY-2N-1,2-BENZOTHIAZIN-3-CARBOXAMIDE |
0 |
|
SU1491339A3 |
| METHOD OF PREPARING 1-OXY-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE-1,1-DIOXIDES OR THEIR SALTS WITH INORGANIC OR ORGANIC BASES |
0 |
- Gyunter Trummlitts
- Volfkhard Engel
- Ernst Zeeger
- Gyunter Engelkhardt
|
SU841588A3 |
| METHOD OF OBTAINING 4-OXY-2-METHYL-N-2-PYRIDYL-2H-1,2-BENZTHIAZINE-3-CARBOXAMIDE-1,1-DIOXIDE |
0 |
|
SU1122224A3 |
| DERIVATIVES OF BENZATHIAZINES |
1991 |
- Khose Migel' Ribalta-Baro[Es]
- Khordi Frigola-Konstansa[Es]
|
RU2032679C1 |
