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2 109 738

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IPC

(21) (22)

Application

93011593/04, 1993-03-02

(22)

Actual filing date

1993-03-02

(45)

Published

1998-04-27

(72)

Inventor

Medvedeva A.S.Podskrebyshev A.I.Safronova L.P.Voronkov M.G.Zaks A.S.

(73)

Holder

Irkutskij Institut Organicheskoj Khimii So RanAktsionernoe Obshchestvo Korporatsija

METHOD OF SYNTHESIS OF 3-ALKOXYCARBONYL-4-HYDROXY-2-METHYL-2H- -1,2-BENZOTHIAZINE-1,1-DIOXIDES Russian patent published in 1998 - IPC

Abstract RU 2109738 C1

FIELD: chemistry of heterocyclic compounds. SUBSTANCE: product: 3-alkoxycarbonyl- -4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxides. Yield is 73%. Reagent 1: saccharin. Reagent 2: monochloroacetic acid ester. Reaction conditions: in medium of dimethylformamide, at increased temperature, in the presence of potassium carbonate, at equimolar ratio of reagents. Obtained reaction mixture is treated with sodium alcoholate and then with methylating agent. Synthesized compound is used for synthesis of intermediate nonsteroid compounds for synthesis of antiinflammatory agents. EFFECT: improved method of synthesis, high yield of product. 2 cl

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RU 2 109 738 C1

Authors

Medvedeva A.S.

Podskrebyshev A.I.

Safronova L.P.

Voronkov M.G.

Zaks A.S.

Dates

1998-04-27—Published

1993-03-02—Filed