FIELD: agriculture. SUBSTANCE: desired product (22R)-20-3′-isopropylisoxazoline-5-yl)-3α, 5- cyclo-5a-pregnane-6-on has essential formula 3′, its melting point being 185-187 C. (20R)-2-formyl-3α,5-cyclo-6,6-ethylenedioxy-5a- pregnane is used as reagent 1. Methylene triphenylphosphorane is used as reagent 2. Reaction is carried out at room temperature in the medium of tetrahydrofuran in the presence of butyl lithium. Isobutyro nitrile oxide also may be used as reagent 2, then reaction is carried out in chloroform in the presence of pyridine. EFFECT: improves quality of desired product. 3 tbl
Authors
Dates
1996-01-27—Published
1990-09-24—Filed