METHOD OF CEPHEME DERIVATIVES SYNTHESIS Russian patent published in 1994 - IPC

Abstract RU 2007408 C1

FIELD: organic chemistry. SUBSTANCE: cepheme derivatives of the general formula (1), where R1 - amino- or protected amino-group; R2 - a lower alkyl or fluoromethyl; R3-COO, carboxylic or protected carboxylic-group; R4 - hydroxy(lower)alkyl or protected hydroxy(lower)alkyl; R5 - amino- or protected amino-group; R6 - hydrogen or methyl. Reagent 1: compound of the general formula (2), where - carboxy- or protected carboxy-group, J - chlorine, acetoxy-group. Reagent 2: compound of the general formula R3a

(3). Reaction conditions: sodium iodide, iodotrimethylsilane or chlorotrimethylsilane. EFFECT: improved method of synthesis.

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RU 2 007 408 C1

Authors

Kazuo Sakane[Jp]

Kokhdzi Kavabata[Jp]

Kenzi Mijaj[Jp]

Esikhiko Inamoto[Jp]

Dates

1994-02-15Published

1989-08-24Filed