FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: products: new cephem compounds of the general formula 
, where R1 - carboxy (lower) alkyl or esterified carboxy (lower) alkyl; R2 - lower alkyl or hydroxyalkyl; R3 - NH2, lower alkanoylamino- or carbamoylamino; R4 - H, alkyl, or their acid-additive salts. Synthesis is carried from the corresponding derivatives of 7β-[2-(5-amino-1,2,4-thiadiazole-3-yl)-2- (1-carboxyalkylamino)acetamido] -3-chloromethyl-3-cephem-4-carboxylic acid and substituted pyrazole in the medium of N,N-dimethylformamide at the room temperature. New compounds showing antimicrobial activity inhibit pathogenic microorganisms at concentration 0.1-0.2 mg/ml; a single dose is 50-2000 mg, daily dose is up to 4000 mg. EFFECT: improved method of synthesis, increased effectiveness of new compounds. 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING COMPOUNDS OF CEPHEM OR THEIR SALTS | 0 |
|
SU1604160A3 |
| CEPHEM COMPOUND OR ITS PHARMACEUTICALLY ACCEPTABLE SALT | 1992 |
|
RU2024530C1 |
| METHOD OF CEPHEME DERIVATIVES SYNTHESIS | 1989 |
|
RU2007408C1 |
| CEPHEM COMPOUNDS AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1992 |
|
RU2081874C1 |
| ANTIBIOTIC COMPOSITION | 1988 |
|
RU2029549C1 |
| METHOD OF PREPARING CEPHEMIC COMPOUNDS OR THEIR SALTS | 0 |
|
SU1831484A3 |
| METHOD OF SYNTHESIS OF THIAZOLE DERIVATIVES OR THEIRS SALTS WITH HALOID ACID | 1990 |
|
RU2010026C1 |
| METHOD OF CEPHEM COMPOUND OR THEIRS ADDITIVE SALTS WITH ACIDS SYNTHESIS | 0 |
|
SU1787158A3 |
| PROCESS FOR PREPARING DERIVATIVES OF(7-(2-AMINOTHIAZOLYL)-2-OXYMINOACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACIDS OR THEIR ESTERS OR SALTS WITH ALKALI METALS | 0 |
|
SU1098523A3 |
| THIAZOLE DERIVATIVES | 1991 |
|
RU2048468C1 |
