FIELD: organic chemistry, antibiotics. SUBSTANCE: invention proposes new derivatives of cephem of the formula (I) 
where: R1 means amino- or protected amino-group; R2 means lower alkyl that can be substituted with 1-3 halogen atoms; R3 means COO⊖, carboxy- or substituted carboxy-group; R4 means hydroxy(lower)alkyl or protected hydroxy(lower)alkyl; R5 means amino- or protected amino-group; R6 means hydrogen or lower alkyl; X⊖ means trifluoroacetate; n = 0 when R3 means COO⊖ at condition that and n = 1 when R3 means carboxy- or protected carboxy-group, and its pharmaceutically acceptable salt. Synthesized compounds show antibacterial activity. EFFECT: improved method of synthesis. 7 cl, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF CEPHEME DERIVATIVES SYNTHESIS | 1989 |
|
RU2007408C1 |
| METHOD OF CEPHEM COMPOUND OR THEIRS ADDITIVE SALTS WITH ACIDS SYNTHESIS | 0 |
|
SU1787158A3 |
| CEPHEM COMPOUND OR ITS PHARMACEUTICALLY ACCEPTABLE SALT | 1992 |
|
RU2024530C1 |
| METHOD OF SYNTHESIS OF CEPHEM COMPOUNDS OR THEIR ACID-ADDITIVE SALTS | 1988 |
|
RU2017744C1 |
| PROCESS FOR PREPARING DERIVATIVES OF(7-(2-AMINOTHIAZOLYL)-2-OXYMINOACETAMIDO)-3-CEPHEM-4-CARBOXYLIC ACIDS OR THEIR ESTERS OR SALTS WITH ALKALI METALS | 0 |
|
SU1098523A3 |
| ANTIBIOTIC COMPOSITION | 1988 |
|
RU2029549C1 |
| PYRAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1993 |
|
RU2128172C1 |
| METHOD OF PRODUCING COMPOUNDS OF CEPHEM OR THEIR SALTS | 0 |
|
SU1604160A3 |
| METHOD OF PRODUCING 3-VINYLCEPHALOSPORINS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 0 |
|
SU1186087A3 |
| METHOD OF PREPARING CEPHEMIC COMPOUNDS OR THEIR SALTS | 0 |
|
SU1831484A3 |
