METHOD OF PRODUCING 2,3-BIS-AROYLMETHYLENE-1,2,3,4-TETRAHYDROQUINOXALINES Russian patent published in 1994 - IPC

FIELD: medicine. SUBSTANCE: desired product are: 2-p-brominebenzoylmethylene3-benzoylmethylene-1,2,3,4-tetrahydroquinoxaline having empirical formula C₂₄H₁₇BrN₂O₂ and melting point 201-202 C and 2-p-nitrobenzoylmethylene-3-benzoylmethylene-1,2,3,4-tetrahydroquinoxaline having empirical formula C₂₄H₁₇N₃O₄ and melting point 220-221 C. 2-p-brominebenzoylmethylene-5-phenyl-2,3-dihydro-3-furanon or 2-p-nitrobenzoylmethylene-5-phenyl-2,3-dihydro-3-furanon are used as reagent 1. O-phenylenediamine is used as reagent 2. Reaction is carried out at room temperature in organic solvent. Thus prepared product has antimicrobial activity. EFFECT: improves efficiency of the method.