FIELD: organic chemistry. SUBSTANCE: synthesis is carried out by reaction of 4-bromo-5-phenyl (or p-tolyl)-2,3-dihydrofuran-2,3-dione with methoxycarbonylmethylenetriphenylphosphorane in benzene medium at 80 C. The yield, %; m. p. , C; empirical formula: a) 86; 129-130; C13H9BrO4; b) 78; 152-153; C14H11BrO4. New compounds show toxicity LD50 = 620 and above 2000 mg/kg and activity at minimal inhibitory concentration 15 and 31 mcg/ml against 70 and 500 mcg/ml for ethacridine lactate, respictively. EFFECT: synthesis of compounds showing increased activity and decreased toxicity. 1 tbl
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