PYRIDYL- OR PYRIMIDYL-CONTAINING DERIVATIVES OF PIPERAZINE OR 1,4-DIAZACYCLOHEPTANE OR THEIR PHARMACOLOGICALLY ACTIVE ACID-ADDITIVE SALTS SHOWING PSYCHOTROPIC ACTION Russian patent published in 1994 - IPC

Abstract RU 2021269 C1

FIELD: organic chemistry. SUBSTANCE: products: pyridyl- or pyrimidyl-containing derivatives of piperazine or 1,4-diazacycloheptane of the general formula (I) where R₁ - hydrogen or fluorine; X - oxygen, sulfur or methylene; n = 2 or 3; A - 2-pyridyl group C₅H₂NR₂R₃ or 2-pyrimidyl group C₄H₃N₂; when A is 2-pyrimidyl group then X is oxygen or methylene and n = 2; R₂ - hydrogen or chlorine; R₃ - hydrogen, lower alkyl, chlorine, hydroxy, lower alkoxy, nitro, trifluoromethyl, carbamoyl, N-methylcarbamoyl, morpholinocarbonyl or piperidinocarbonyl group, or their pharmacologically active acid-additive salts. Reagent 1: compound of the general formula where R₁, X and n - as indicated above. Reagent 2: 2X-C₅H₂NR₂R₃ or 2-Z-C₄H₃N₂ where R₂ and R₃ - as indicated above, Z - halide. Conditions: heating in the presence of base. Synthesized compounds are used in medicine for mental disorders treatment. EFFECT: improved method of synthesis of compounds indicated above. 1 tbl

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RU 2 021 269 C1

Authors

Olsson Knut Gunnar[Se]

Abramo Aina Lisbet[Se]

Torb'Ern Ehrik[Se]

Nordvi Kurt[Se]

Dates

1994-10-15—Published

1989-09-27—Filed