N-(HETERO)ARYL -N-(HETERO)TETRALINEALKYL PIPERAZINES AND METHOD OF PREPARING THEREOF Russian patent published in 1998 - IPC

Abstract RU 2115651 C1

FIELD: chemistry of heterocyclic compounds, more particularly, medicine. SUBSTANCE: present invention describes novel N-(hetero) aryl-N-(hetero)-tetralinealkyl piperazines having serotoninergic, dopaminergic and adrenergic activities of general formula I: wherein Ar1 is phenyl or thienyl condensed with 5 or 6-membered carbocyclic ring; R1 and R2 are independently H or C1-5 alkoxy; Ar2- is phenyl unsubstituted or substituted by methoxy, halogen, trifluoromethyl, or pyridyl; is selected from wherein n is 1 or 2; m is 2 or 3, and pharmaceutically acceptable salts thereof. The claimed methods make it possible to prepare the desired product derived from compound of formula (I): and corresponding piperazine containing reagent. EFFECT: improved properties of the title compound. 10 cl, 3 tbl

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RU 2 115 651 C1

Authors

Roberto Perrone

Franchesko Berardi

Franchesko Fiorentini

Stefano Govoni

Vinchentso Oldzhiati

Ehrmes Vanotti

Marino Gobetti

Dzhankarlo Tonon

Dates

1998-07-20Published

1993-06-22Filed