METHOD OF SYNTHESIS OF GRISEOLIC ACID DERIVATIVE OR ITS ESTER Russian patent published in 1994 - IPC

Abstract RU 2021282 C1

FIELD: organic chemistry. SUBSTANCE: product of the formula (I) or its ester. Reagent 1: dimethyl ester of 5-deamino-2-(N',N'-dimethylaminomethylene)-amino-6-hydroxygrise- olic acid. Reagent 2: nitrite. Reaction conditions: in aqueous solution of acetic acid, at the room temperature. Synthesized compounds inhibit activity of phosphodiesterase. EFFECT: improved method of synthesis. 1 tbl

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Authors

Kaneko Masakatsu[Jp]

Murofusi Esinobu[Jp]

Kimura Misako[Jp]

Jamazaki Mitsuo[Jp]

Indzima Jasuteru[Jp]

Dates

1994-10-15Published

1988-03-30Filed