METHOD OF SYNTHESIS OF OPTICALLY ACTIVE INDOLOBENZOQUINOLINE DERIVATIVE OT ITS PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: compound of the formula (I) where R₁ H, C₁-C₄, X^b and Y^b are similar or different and each is hydrogen atom or hydroxy-group; Z -NR^aR^b where R^a and R^b are similar or different and each is hydrogen, alkyl, hydroxyalkyl, C₁-C₄-cyclic amino- group consisting of 3-6 C-atoms. Reagent 1: compound of the formula (Ia) where R₁ as indicated above, R₂ carboxy-protective group, X_a and Y_a are similar or different and mean hydrogen atom or protected hydroxyl group. Reagents of compounds of the formulas (2) , (3) , (4) , (5) R₃OH 5, (6) , (7) R₄Q 7, (8) Q-A-Q₁ 8, respectively, and structures of compounds of formulas (I) and (II). Synthesized compounds show antiarrhythmic activity. EFFECT: improved method of synthesis. 7 dwg, 2 tbl