HEXAHYDRONAPHTHALENE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: products: hexahydronaphthalene ester compounds of the formula (I): where R¹ means group of the formula (II) or (II) ; R⁵ means hydrogen atom; R^a means hydroxy-group; R^6a means hydrogen atom or hydroxy-protective group, and/or (A) R² means ethyl group; R³ means alkyl group having 1-4 carbon atoms or alkenyl group having 2-6 carbon atoms, and R⁴ means alkyl group having 2-4 carbon atoms or alkenyl group having 2-5 carbon atoms; or (b) R² means propyl group; R³ means hydrogen atom, and R⁴ means propyl group; or (c) R² means butyl group; R³ means methyl group, and R⁴ means methyl group, and its pharmaceutically acceptable salts. 2. Compound as at point 1 where: R² means ethyl group; R³ means alkyl group having 1-4 carbon atoms or allyl group; and R⁴ means alkyl group having 2-4 carbon atoms or allyl group. 3. Compound as points 1 or 2 where: R¹ means group of the formula (II) . 4. Compound as at point 3 where R^6a means hydrogen atom. 5. Compound as at point 1 where: means ethyl group; R³ means alkyl group having 1-3 carbon atoms; and R⁴ means alkyl group having 2 or 3 carbon atoms. Invention proposes pharmaceutical composition inhibiting biosynthesis of cholesterol and involving compounds of the formula (I) as an active component and pharmaceutically acceptable carrier. EFFECT: improved method of synthesis. 9 cl, 10 tbl