FIELD: organic chemistry. SUBSTANCE: product - derivative of dihydropyrimidothiazine of formula (I) where R1-C1-C6-alkoxy or phenylamino-group, R2-C1-C6-alkyl or phenyl, R3 - hydrogen or C1-C6-alkyl, R4-C1-C6-alkyl or phenyl which can be substituted with one or some similar or different substituents of halogen group, nitro, C1-C6- dialkylamino-groups, C1-C6-alkyl, C1-C6-alkoxy or hydroxy-group, or their therapeutically acceptable salt of acid binding. Reagent 1: derivatives of 1,2,3,4-tetrahydro-2-pyrimidinethione of formula (II). Synthesized compounds are used in medicine as agents showing antianginal and antiinflammatory activity. EFFECT: improved method of synthesis. 2 cl, 4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING CONDENSED DERIVATIVES OF PYRIMIDINE, THEIR PHARMACEUTICALLY ACCEPTABLE ACID ADDITIVE SALTS OR ACID ADDITIVE SALTS OF HYDRATES | 0 |
|
SU1650014A3 |
| PROCESS FOR PRODUCTION OF DERIVATIVES OF TRIASOLOPYRIMIDINE OR MIXTURE THEREOF OR THEIR PHARMACEUTICALLY-ACCEPTABLE SALTS WITH METALS | 0 |
|
SU1776261A3 |
| BICYCLIC PYRIDINES AND ANALOGUES AS SIRTUIN MODULATORS | 2010 |
|
RU2550821C2 |
| THIOACID AMIDE DERIVATIVES AND FOOD COMPOSITION FOR THE USE IN CATTLE BREEDING | 1991 |
|
RU2060995C1 |
| DERIVATIVES OF 1,2,4-TRIAZOLYLTHIOAMIDES | 1990 |
|
RU2045521C1 |
| DERIVATIVES OF 5-(AMINO-SUBSTITUTED)-1,2,4-TRIAZOLO-[1,5-A]-PYRIMIDINE, THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, PHARMACEUTICAL COMPOSITION SHOWING CARDIOTONIC AND CORONARY-DILATING ACTION AND A METHOD OF CARDIOTONIC AND/OR CORONARY-DILATING EFFECT ON HEART | 1992 |
|
RU2097382C1 |
| TRICYCLIC NITROGEN-CONTAINING COMPOUNDS AND TETRAHYDROQUINOLINE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1991 |
|
RU2023712C1 |
| LIQUID MEDICINAL FORM OF PIROXICAM | 1991 |
|
RU2062616C1 |
| DERIVATIVES OF TRIAZOLYLHYDRAZIDE AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2039051C1 |
| METHOD OF SYNTHESIS OF QUINOLINE CARBOXYLIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND COMPOUNDS | 1990 |
|
RU2044734C1 |
