FIELD: organic chemistry. SUBSTANCE: products: derivatives of 1,2,4-triazolylthioamides of the formula (I) where Q - hydrogen, (lower) alkylthio-group or NR1R2-group where R1 and R2 hydrogen lower alkyl or lower alkenyl or R1 and R2 bound with nitrogen atom form morpholino, piperidino or 4-methylpiperazino-group. Y C1-C4-alkyl substituted for hydroxyl or one or two C1-C4-groups, di-C1-C4-alkoxyphenyl-C1-C4-alkyl or phenoxy-C1-C4-alkyl substituted with C1-C4-alkyl at phenyl end and this alkyl has piperidino-group, or their acid-additive pharmaceutically acceptable salts. Reagent 1: triazolyl dithioether of the formula (II) . Reagent 2: amine of the formula (III) YNH2 where Q and Y are indicated above; R4 alkyl-C1-C4. Synthesized compounds show tranquilizing, antidepressant, spasmolytic, antiinflammatory, analgetic and antiperistaltic actions and can be used in chemical-pharmaceutical industry. EFFECT: improved method of synthesis. 5 tbl
Title | Year | Author | Number |
---|---|---|---|
DERIVATIVES OF TRIAZOLYLHYDRAZIDE AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2039051C1 |
DERIVATIVES OF 5-(AMINO-SUBSTITUTED)-1,2,4-TRIAZOLO-[1,5-A]-PYRIMIDINE, THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, PHARMACEUTICAL COMPOSITION SHOWING CARDIOTONIC AND CORONARY-DILATING ACTION AND A METHOD OF CARDIOTONIC AND/OR CORONARY-DILATING EFFECT ON HEART | 1992 |
|
RU2097382C1 |
PROCESS FOR PRODUCTION OF DERIVATIVES OF TRIASOLOPYRIMIDINE OR MIXTURE THEREOF OR THEIR PHARMACEUTICALLY-ACCEPTABLE SALTS WITH METALS | 0 |
|
SU1776261A3 |
DERIVATIVES OF 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND INTERMEDIATE COMPOUND | 1998 |
|
RU2180903C2 |
METHOD OF PRODUCING DERIVATIVES OF DIHYDROARYLOXYALKYLAMINO-1,2,4-TRIAZOLE OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITION SALTS | 0 |
|
SU1480767A3 |
3-(2-SUBSTITUTED PHENYL)-2-(SUBSTITUTED IMNO) THIAZOLIDINES OR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION HAVING ANTIANGINAL AND/OR ANTINEUROLOGICAL EFFECT | 1992 |
|
RU2065855C1 |
DIHYDROPYRIMIDOTHIAZINE DERIVATIVES OR THEIR THERAPEUTICALLY ACCEPTABLE SALTS OF ACID BINDING SHOWING ANTIANGINAL AND ANTIINFLAMMATORY ACTIVITY | 1990 |
|
RU2022965C1 |
METHOD OF PREPARING FLUOXETIN | 1997 |
|
RU2173679C2 |
THIOACID AMIDE DERIVATIVES AND FOOD COMPOSITION FOR THE USE IN CATTLE BREEDING | 1991 |
|
RU2060995C1 |
METHOD OF SYNTHESIS OF 6,7-DICHLORO-1,5-DIHYDROIMIDAZO-[2,1-B]-QUINAZOLINE-2-(3H)-ONE, INTERMEDIATES FOR THEIR SYNTHESIS AND A METHOD OF THEIR SYNTHESIS | 1992 |
|
RU2042678C1 |
Authors
Dates
1995-10-10—Published
1990-11-23—Filed