FIELD: organic chemistry. SUBSTANCE: product - 4-substituted anthracyclinones of the formula (I). Anthracycline glycoside of the formula (II). Reagent 1: 4-demethyl-4- sulfonyl-13 -dioxosolanyldaunomycin. Reagent 2: unsaturated compounds of the formulaH-R'' where R'' - alkenyl, alkinyl. Reagent 3: organometallic compound of the formula MRnYm where M - metal atom, R - linear or branched alkenyl or alkinyl containing up to 4 carbon atoms. Reaction conditions: catalytic quantity of compound of the formula (III): 
where M' - transient metal atom, L,L' - anion or neutral molecule; p and q - meanings from 0 to 4. Synthesized compounds are used in medicine. EFFECT: improved method of synthesis. 5 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| PROCESS FOR PREPARING 4-SUBSTITUTED ANTHRACYCLINONES | 1989 |
|
RU2071463C1 |
| ANTHRACYCLINE GLYCOSIDE AND METHOD OF ITS SYNTHESIS | 1990 |
|
RU2073681C1 |
| METHOD FOR PRODUCTION OF ANTHRACYCLONES | 1990 |
|
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| COMPOUNDS OF CEPHEM AND ITS PHARMACEUTICALLY AND VETERINARY ACCEPTABLE SALTS AND METHOD FOR THEIR PRODUCTION | 1990 |
|
RU2074186C1 |
| 8-FLUOROANTHRACYCLINE GLYCOSIDES OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, INTERMEDIATE COMPOUNDS, AND METHOD OF PREPARATION THEREOF | 1991 |
|
RU2095365C1 |
| ANTHRACYCLINE GLYCOSIDE AND METHOD OF ITS SYNTHESIS | 1992 |
|
RU2081878C1 |
| METHOD OF PRODUCING ANTRACYCLIN GLYCOZIDES | 0 |
|
SU1614764A3 |
| ANTHRACYCLINE GLYCOSIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING ANTITUMOR PROPERTIES, AND A METHOD OF THEIR SYNTHESIS | 1990 |
|
RU2043360C1 |
| METHOD OF PRODUCING ANTHRACYCLINIC GLYCOSIDES | 0 |
|
SU1553015A3 |
| METHOD OF PRODUCING ANTHRACYCLINEGLYCOSIDES | 0 |
|
SU1378784A3 |
