COMPOUNDS OF CEPHEM AND ITS PHARMACEUTICALLY AND VETERINARY ACCEPTABLE SALTS AND METHOD FOR THEIR PRODUCTION Russian patent published in 1997 - IPC

FIELD: pharmacology, veterinary. SUBSTANCE: desired compounds have common formula where m=1 or 2, n=0, 1 or 2, A is lower alkyl, naphthyl or optionally substituted phenyl, B is lower alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, phenyl or heteryl; R¹ is halogen, lower alkoxyl, R² is lower akyl, lower alkanoyloxymethyl or -CH₂-S-Het group where Het is heteryl. Said compounds having formula are prepared by interaction of compound having formula with halogenating agent. Thus obtained product having formula is affected by interaction with compound having formula MS(O)_bB where M is hydrogen or cation of metal. Compound having formula is prepared by interaction of compound having formula with compound having formula ZS(O)_nB where Z is leaving group. Said interaction is carried out in the presence of organic or inorganic base in aprotic polar or nonpolar solvent at (-60)-(+40) C. EFFECT: improved quality of desired product, improved efficiency of the method. 6 cl, 4 tbl