FIELD: organic chemistry, antibiotics. SUBSTANCE: product: anthracycline glycoside of the formula (I) 
where: R1 - hydrogen, F, -OH or NH2; R2 and R3 - both mean -OH or one of R2 and R3 means H, NO2 or NH2 and other - -OH; R4-CH3 or CH2OH. Reagent 1: the corresponding aglycone. Reagent 2: 1-haloid-2,3,4,6-tetradeoxy-4-(N-trifluoroacetamido)-L-erythrohexapyranoside. The following reaction are possible: a) conversion of the end product to pharmaceutically acceptable salt; b) transformation of radicals R2 or R3 from nitro- to amino-group; c) transformation of radical R4 through bromo-derivative. Synthesized compounds were used in medicine as antitumor agents. EFFECT: improved method of synthesis. 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTHRACYCLINE GLYCOSIDE AND METHOD OF ITS SYNTHESIS | 1992 |
|
RU2081878C1 |
| ANTHRACYCLINE GLYCOSIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING ANTITUMOR PROPERTIES, AND A METHOD OF THEIR SYNTHESIS | 1990 |
|
RU2043360C1 |
| 8-FLUOROANTHRACYCLINE GLYCOSIDES OR PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, INTERMEDIATE COMPOUNDS, AND METHOD OF PREPARATION THEREOF | 1991 |
|
RU2095365C1 |
| METHOD OF PRODUCING ANTHRACYCLINIC GLYCOSIDES | 0 |
|
SU1553015A3 |
| PROCESS FOR PREPARING 4-SUBSTITUTED ANTHRACYCLINONES | 1989 |
|
RU2071463C1 |
| 4-SUBSTITUTED ANTHRACYCLINONES AND ANTHRACYCLINE GLYCOSIDE | 1991 |
|
RU2024483C1 |
| N-IMIDAZOLYL DERIVATIVES OF THE SUBSTITUTED ALKOXYIMINOTETRAHYDRONAPHTHALENES OR CHROMANES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY OF THROMBOXANE ANTAGONIST AND THROMBOXANE SYNTHASE INHIBITOR | 1992 |
|
RU2083566C1 |
| METHOD OF PRODUCING ANTRACYCLIN GLYCOZIDES | 0 |
|
SU1614764A3 |
| COMPOUNDS OF CEPHEM AND ITS PHARMACEUTICALLY AND VETERINARY ACCEPTABLE SALTS AND METHOD FOR THEIR PRODUCTION | 1990 |
|
RU2074186C1 |
| 3-DEOXYMANNOSEAMINE DERIVATIVE, A METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING INHIBITING EFFECT ON VESSEL AND METASTASIS DEVELOPMENT | 1992 |
|
RU2099333C1 |
