METHOD OF SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS Russian patent published in 1994 - IPC

FIELD: organic synthesis. SUBSTANCE: product of the general formula where Ar - phenyl substituted with one or more halogens, (C₁-C₃)-haloalkyls or (C₁-C₄)-haloalkoxy-groups; K, X₁, Z mean independently each of other O, B₁ and B₂ which can be similar or different and mean linear or branched (C₁-C₆)-alkylidenes; Rh means (C₁-C₆)-haloalkyl containing from 1 to 9 halogen atoms, (C₃-C₈)-haloalkoxyalkyl where halogen is fluorine or chlorine; A means nitrogen heterocyclic group taken from imidazoles, imidazoles substituted with C₁-C₆-alkyls or pyridine. Reagent 1: compound of the formula Ar-X₁-B₁-Y where Ar, X₁ and B₁ - as indicated above, Y - halogen. Reagent 2: amine of the formula NA₂-B₂, -ZH where B₂ and Z - as indicated above. Medium is an organic solvent. Reagent 3: Ar-X₁-B₁-NH-B₂-ZH where Ar, X₁, B₁, B₂, Z - as indicated above. Reagent 4: polyfluoroolefin of the formula CF₂=CX₁X₂ where X₁ - Cl, F, CF₃, OCF₃; X₂ - F, CH₃ in dipolar aprotonic or alcoholic solvent in the presence of strong base, at 5 C. Reagent 5: carbonyl derivative of imidazole, substituted imidazole or pyridine, in aromatic or halogenated solvent, at 80 C. EFFECT: improved method of synthesis. 2 tbl