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2 024 520

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Application

5028322/04, 1991-10-08

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Actual filing date

1991-10-08

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Published

1994-12-15

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Inventor

Tolstikov G.A.Shul'Ts Eh.Eh.Mukhametjanova T.Sh.Tolstikova T.G.Popov V.G.Zarudij F.A.Davydova V.A.Lazareva D.N.

(73)

Holder

Institut Organicheskoj Khimii Ural'Skogo Otdelenija Ran

METHOD OF SYNTHESIS OF 10-METHOXY -5- METHYL-6- (1',1'- DIOXIDO-2' -METACHLOROPHENYLAZO -3'- HYDROXY -4'-METHOXYBENZO[B] THIOPHENE -7-YL) -5H- 3,4,6,7-TETRA- HYDROFURO[4,3,2-Q] [3]BENZAZOCINE Russian patent published in 1994 - IPC

Abstract RU 2024520 C1

FIELD: organic chemistry. SUBSTANCE: product - 10-methoxy -5- methyl-6 -(1′,1′ -dioxido- 2-meta-chlorophenylazo -3′- hydroxy -4'- methoxybenzo[b] thiophene-7-yl)-5H-3,4,6,7-tetr - ahydrofuro [4,3,2-Q][3] benzazocine, empirical formula is C19H26ClN3O6, yield is 80%, m. p. is 205-208 C. Reagent 1: 10-methoxy -6- (4′-methoxy -1′, 1′, 3′- trioxo-2′, 3′-dihydrobenzothienyl - 7′) -5-methyl -3,4,6,7- tetrahydro-5H- furo[4,3,2-Q][3]benzazoci- ne. Reagent 2: diazonium salt prepared from meta-aniline and sodium nitrite in aqueuos HCl. Reaction conditions: azo coupling reaction in the mixture of pyridine and water at 5 C firstly and then at the room temperature. Synthesized compound is used in medicine. EFFECT: improved method of synthesis. 4 tbl

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RU 2 024 520 C1

Authors

Tolstikov G.A.

Shul'Ts Eh.Eh.

Mukhametjanova T.Sh.

Tolstikova T.G.

Popov V.G.

Zarudij F.A.

Davydova V.A.

Lazareva D.N.

Dates

1994-12-15—Published

1991-10-08—Filed

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