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1 764 303

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A1

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Application

4902356/04, 1990-11-26

(22)

Actual filing date

1990-11-26

(45)

Published

1994-06-15

(72)

Inventor

Tolstikov G.A.Baltina L.A.Tolstikova T.G.Popov V.G.Davydova V.A.Zarudij F.A.Chupakhin O.N.

GLYCYRRHIZIC ACID TRIAMIDE WITH 4-PHENYL-2-AMINOTHIAZOLE SHOWING ANTIDEPRESSANT ACTIVITY Russian patent published in 1994 - IPC

Abstract SU 1764303 A1

FIELD: organic chemistry. SUBSTANCE: product: (3-0)-[2-0-N-β-D-glucopyranosyluranoyl-4- phenyl-2-aminothiazole)-N-b-D-glucopyranosylura-noyl-4- phenyl-2-amintothiazole] -(3 b, β,20 C69H80N60O13S3-11,30-dioxo-30-N-4-phenyl-2-amino-thiazole)-30-norlean-12-en, gross-formula is [α]2D

, m.p. is 168-171 C, N′ = +37 rotation degree (c = 0.04, dioxane), yield is 77.2%. Reagent 1: glycyrrhizic acid. Reagent 2: 4-phenyl-2-aminothiazole. Reaction condition: in the medium of dimethylformamide in the presence of pyridine and N, N'-dicyclo-hexylcarbodiimide. Synthesized compound is used as an antidepressive agent. EFFECT: higher efficiency. 4 ex, 3 tbl

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SU 1 764 303 A1

Authors

Tolstikov G.A.

Baltina L.A.

Tolstikova T.G.

Popov V.G.

Davydova V.A.

Zarudij F.A.

Chupakhin O.N.

Dates

1994-06-15—Published

1990-11-26—Filed

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