FIELD: organic chemistry, carbohydrates. SUBSTANCE: synthesis is carried out by reaction of 2,3,4,6- tetra-O- acetyl -b-D-galactopyranosyl -fluoride with 2-cyano-6- trimethylsilylhydroxybenzthiazole in the medium of nonpolar organic solvent (benzene) in the presence of boron trifluoride etherate with isolation and purification of intermediate 6-(2-cyanobenzthiazolyl) -2,3,4,6-tetra -O-acetyl-b -D-galacto- pyranoside by chromatography following by its deacetylation and condensation with D-cysteine. Deacetylation product can be purified by chromatography and crystallization methods. New method ensures to prepare the end product from available reagents with good yield (61%) and provides high sensitivity of b-galactosidase activity detection by bioluminescent method. EFFECT: development of new method of synthesis of substance indicated above. 1 dwg
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Authors
Dates
1994-12-15—Published
1990-03-13—Filed