FIELD: chemistry; pharmacology.
SUBSTANCE: invention refers to method of 6-O-[β-D-(2,3,4,6-tetra-O-acetyl)glucopyranosyl]-d,1-α-tocopherol (1)
or 6-O-[β-D-(2,3,4,6-tetra-O- acetyl)galactopyranosyl]-d,1-α-tocopherol (2)
, consisting in interaction of α-tocopherol and α- or β-anomer of related D-gluco- or D-galactopyranose pentaacetates with added catalyst systems: BF3·OEt2 ionic liquid [bmim]PF6 at mole ratio α-tocopherol:sugar pentaacetate: BF3·OEt2:[bmim]PF6 = 1:1:2.5:0.3-5, in methylene chloride within 3 h at room temperature.
EFFECT: given compounds are precursors of related deacetylated glycosides with observed antiallergic and anti-inflammatory activity.
1 cl, 8 ex
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