FIELD: chemical technology. SUBSTANCE: product: 2,5-dimethylpiperidone-4, yield is 32.1%, duration of technological cycle is 40 h. Reagent 1: acetoacetic ether. Reagent 2: ammonia. Reaction conditions: in aqueous medium. Reagent 3: hydrogen. Reaction conditions: hydrogenation on the nickel catalyst at 60-80 atm, at 35-40 C. Reagent 4: methylmethacrylate. Reaction conditions: at molar ratio of reagent 4:intermediate product = (2-5):1, in the presence of acidic catalyst in the medium of proton-donating solvent at 90-100 C. Reagent 5: technical sodium methylate. Reaction conditions: with simultaneous distillation off of methanol and ethanol forming in the process of reaction. EFFECT: improved method of synthesis. 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| 0 |
|
SU485595A3 | |
| METHOD FOR SYNTHESIS ALKYL METHACRYLATES | 2009 |
|
RU2411231C2 |
| ETHYL AND 3-(N,N-DIMETHYLAMINO)-2,2-DIMETHYPROPYL DIESTER OF 2,5-DIMETHYL-4-(3-NITROPHENYL)-1,4- DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID HYDROCHLORIDE SHOWING PROLONGED ANTIHYPERTENSION EFFECT | 1991 |
|
RU2043341C1 |
| METHOD OF PREPARING 2,2,4-TRIMETHYL-3-HYDROXYPENTYL ISOBUTYRATE BASED ESTERS | 1995 |
|
RU2114099C1 |
| 0 |
|
SU525673A1 | |
| METHOD FOR PRODUCING N,N-BIS(3-AMINOPROPYL)DODECYLAMINE | 2021 |
|
RU2772469C1 |
| METHOD OF PRODUCING N,NЪ-BIS-PARA - CARBOMETHOXYBENZOYLHEXAMETHYLENEDIAMINE | 0 |
|
SU1389676A3 |
| METHOD OF PRODUCING 5-CHLORMETHYL-1,3-DIOXOLAN-4-ON | 0 |
|
SU609290A1 |
| 0 |
|
SU332073A1 | |
| METHOD OF SYNTHESIS OF MENTHYL VALERATE | 1991 |
|
RU2036897C1 |
