STRAIN OF MALIGNANT RHABDOMYOSARCOMA PA-23 CELLS IN RAT USED AS A MODEL FOR RESEARCH OF ORGANOTROPIC METASTASIZING PROCESSES AND SCREENING OF ANTITUMOR AGENTS Russian patent published in 1995 - IPC

Abstract RU 2026344 C1

FIELD: biotechnology, medicine. SUBSTANCE: strain is prepared by prolonged mass selection (262 cycles) to increase metastatic potential and accelerate metastasis rate formation on the basis of rhabdomyosarcoma strain showing affinity for PA-2. Strain is passaged in white mongrel rats by intravenous administration of single cells suspension after 17-19 days. Strain shows high metastatic activity, rapid formation and growth of pulmonary metastasis, the presence of marker protein p58-receptor of cell surface which is necessary for realization of tumor cell capability to metastasis. EFFECT: improved properties of strain proposed. 1 dwg

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RU 2 026 344 C1

Authors

Kaminskaja E.V.

Guzhova I.V.

Fedorova E.V.

Stepan'Jan L.I.

Vakhtin Ju.B.

Dates

1995-01-09—Published

1991-06-26—Filed