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2 353 623

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IPC

C07J53/00(2006-01-01)

C07J63/00(2006-01-01)

A61K31/56(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2007134627/04, 2007-09-17

(24)

Start date

2007-09-17

(22)

Actual filing date

2007-09-17

(45)

Published

2009-04-27

(72)

Inventor

Tolstikova Tat'Jana GenrikhovnaTolstikov Genrikh AleksandrovichSorokina Irina Vasil'EvnaShul'Ts Ehl'Vira EhduardovnaPetrenko Natal'Ja IvanovnaSalakhutdinov Nariman Faridovich

(73)

Holder

Novosibirskij Institut Organicheskoj Khimii Im. N.N. Vorozhtsova So Ran So Ran)

CORRECTOR OF CYTOSTATIC POLYCHEMOTHERAPY Russian patent published in 2009 - IPC C07J53/00 C07J63/00 A61K31/56 A61P35/00

Abstract RU 2353623 C1

FIELD: chemistry.

SUBSTANCE: invention relates to correctors of cytostatic polychemotherapy. As corrector claimed is use of betulonic acid β-alanylamide of formula (I): which potentiates anti-tumor effect and antimetastatic activity of polychemotherapy (PCT), demonstrates antioxidative and cytoprotecting activity at background of tumor PCT, and also produces anti-toxic impact when complex of cytostatic medications is introduced into organism. Compound (I) is synthesised from plant betulin truterpenoid.

EFFECT: obtaining corrector of cytostatic polychemotherapy.

1 cl, 9 ex, 12 tbl

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RU 2 353 623 C1

Authors

Tolstikova Tat'Jana Genrikhovna

Tolstikov Genrikh Aleksandrovich

Sorokina Irina Vasil'Evna

Shul'Ts Ehl'Vira Ehduardovna

Petrenko Natal'Ja Ivanovna

Salakhutdinov Nariman Faridovich

Dates

2009-04-27—Published

2007-09-17—Filed