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2 027 700

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Application

4948225/04, 1991-06-24

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Actual filing date

1991-06-24

(45)

Published

1995-01-27

(72)

Inventor

Krasavtsev Ivan Ivanovich[Ua]Korotkij Jurij Vasil'Evich[Ua]Shavaran Sergej Sergeevich[Ua]Lozinskij Miron Onufrievich[Ua]Klebanov Boris Markovich[Ua]

(73)

Holder

Institut Organicheskoj Khimii An Ukrainy

7-ALKOXY -4-OXA -1,2,6- TRINITRATEHEPTANETRIOLS SHOWING CARDIOTONIC ACTIVITY Russian patent published in 1995 - IPC

Abstract RU 2027700 C1

FIELD: organic chemistry. SUBSTANCE: product - 7-alkoxy-4-oxa-1,2,6-trinitrateheptanetriol of the formula CH(ONO)₂CH(ONO₂)CH₂OCH₂CH(ONO₂)CH₂OR where were indicated: R; empirical formula; n2D

⁰; yield in %: CH₂CF₃; C₉H₁₃N₃F₄O₁₁;; 1.4328; 70; CH₂CF₂CHF₂; C₉H₁₃N₃F₄O₁₁; 1.4318; 75. Reagent 1: epichlorohydrin. Reagent 2: glyceric ether. Reaction conditions: in aqueous medium in the presence of NaOH and triethylbenzylammonium chloride at 35 C for 2 h. Reagent 3: trifluoroethanol. Reaction conditions: in 50% NaOH at 80 C for 4 h. Reagent 4: water. Reaction conditions: for 4 h. Reagent 5: 95% HNO₃. Reaction conditions: in the presence of H₂SO₄ at 10 C. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 2 tbl

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RU 2 027 700 C1

Authors

Krasavtsev Ivan Ivanovich[Ua]

Korotkij Jurij Vasil'Evich[Ua]

Shavaran Sergej Sergeevich[Ua]

Lozinskij Miron Onufrievich[Ua]

Klebanov Boris Markovich[Ua]

Dates

1995-01-27—Published

1991-06-24—Filed