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1 829 346

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IPC

(21) (22)

Application

4923748/04, 1991-04-01

(22)

Actual filing date

1991-04-01

(45)

Published

1996-01-10

(72)

Inventor

Arutjunjan N.S.Akopjan L.A.Garibjan K.M.Shaginjan K.S.Tosunjan A.O.Aleksanjan A.R.Gerasimjan D.A.Movsisjan V.A.

DIHYDROCHLORIDES OF N-[β-(1,2,5-TRIMETHYL-4-ARYLPYPERIDINE-4-YL)ETHYL]- -N-ALKYL-N-(3,4-DIMETOXYBENZYL AMINES BEING INHIBITORS OF CALCIUM-CALMODULIN DEPENDENT PROCESSES Russian patent published in 1996 - IPC

Abstract SU 1829346 A1

FIELD: organic chemistry. SUBSTANCE: desired compounds have common formula is given in the description of the invention. 1,2,5-trimethyl-4-aryl-4-cyanomethyl piperidine is used as reagent 1, LiAlH₄ being used as reagent 2. Veratrole aldehyde is used as reagent 3. Reaction is carried out by boiling in benzene. NaBH₄ is used as reagent 4. Reaction is carried out at 20 C in methanol. Formalin is used as reagent 5. Reaction is carried out at 95-98 C in the medium of formic acid. HCl is used as reagent 6. Reaction is carried out in ether medium. EFFECT: searches compounds having low toxicity which inhibit calcium-calmodulin dependent conditions. 1 tbl

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SU 1 829 346 A1

Authors

Arutjunjan N.S.

Akopjan L.A.

Garibjan K.M.

Shaginjan K.S.

Tosunjan A.O.

Aleksanjan A.R.

Gerasimjan D.A.

Movsisjan V.A.

Dates

1996-01-10—Published

1991-04-01—Filed