STRAIN OF VIRUS ECHO 11 TYPE FOR SEROLOGICAL DIAGNOSIS OF ENTEROVIRAL UVEITIS IN CHILDREN Russian patent published in 1995 - IPC

FIELD: virology. SUBSTANCE: strain Karim/A ECHO 11 virus is isolated in 1988 from feces of 11-month old boy with acute uveitis. Strain is deposited in State Collection of Virology Institute at number 2269. Strain Karim/A ECHO 11 virus shows expressed ophthalmotropism in monkey experiments and represents antigen species of ECHO 11 virus. Strain Karim/A distincts from standard strain Gregory ECHO 11 virus and from ophthalmotropic strain Mop/M ECHO 11 virus by antigenicity in neutralization reaction. Strain Karim/A ECHO 11 virus is used as a diagnostic antigen preparation in neutralization reaction for specific serological diagnosis of enteroviral uveitis in children. Detection in children with uveitis of obscure etiology of antibodies to the strain Karim/A at titer 1:64 and above (usually (1:512)-(1:2048)) is a laboratory proof of etiological involvement of ECHO 11 virus with eye disease which is related with strain Karim/A. EFFECT: detection of virus strain indicated above. 2 tbl