FIELD: organic chemistry. SUBSTANCE: product: 1-(3′-azido-2,3′-dihydroxy-D-erythro-pentofuranosyl)thymidine, yield is 50%. Content of basic substance is 97% . Reagent 1: 5′-O-benzoyl-2,3′-anhydroxythymidine. Reagent 2: sodium azide in the presence of lithium chloride and ammonium chloride at the ratio of all reagents 1:1-1.1:0.25-0.3:0.3:0.35, respectively, at 98-102 C following by treatment with methanol and diethylamine at the ratio 1:1. Preparation is used for AIDS treatment. EFFECT: improved method of synthesis. 3 cl, 1 tbl
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Authors
Dates
1995-05-10—Published
1992-07-30—Filed