FIELD: organic chemistry, chemistry of nucleosides. SUBSTANCE: invention describes new 3'-(5-R-tetrazole-2-yl)-thymidines of the formula (I) 
where R - hydrogen or lower alkyl exhibiting antiviral activity with respect to human immunodeficiency virus (HIV) and avian myeloblastosis virus (AMV), and a method of synthesis of 3'-(5-R-tetrazole-2-yl)-thymidines. Method involves treatment of 5'-O-protected 2,3'-anhydrothymidine with tetrazole derivative of the general formula (II) 
where R - as indicated above in the presence of trialkylamine in medium of aprotonic dipolar solvent followed by hydrolytic splitting off a protective 5'-O-benzoyl group and isolation of the end product. Synthesized compounds are used in medicine for treatment of patients and animals with viral infections. EFFECT: new thymidine derivatives indicated above, improved method of synthesis. 2 cl, 3 tbl, 3 ex
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Year |
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Number |
| METHOD OF SYNTHESIS OF 3'-AZIDO-2',3'-DIDEOXYTHYMIDINE |
1997 |
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- Bezklubnaja E.V.(Ru)
- Kononov A.V.(Ru)
|
RU2135512C1 |
| DERIVATIVES OF 3'-AZIDO-3'-DEOXYTHYMIDINE 5'-H-PHOSPHONATE AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF |
2001 |
- Shirokova E.A.
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RU2187509C1 |
| (-)-ENANTIOMER OF CIS-4-AMINO-1-(2-HYDROXYMETHYL-1,3-OXATHIOLAN-5-YL)-(1H)-PYRIMIDINE-2-ONE, A MIXTURE OF (-)-ENANTIOMER AND (+)-ENANTIOMER, METHOD OF THEIR PREPARING |
1991 |
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RU2099338C1 |
| METHOD OF SYNTHESIS 2'-DEOXYXYLOTHYMIDINE, DERIVATIVES OF D-XYLOFURANOSE, DERIVATIVES OF XYLOTHYMIDINE |
1994 |
- Papchikhin A.V.
- Rumjantseva S.A.
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RU2108339C1 |
| AGENT FOR INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) AND CYTOMEGALOVIRUS (CMV) INFECTIONS AND METHOD OF THEIR INHIBITION |
2002 |
- Miller G.G.
- Kushch A.A.
- Romanova V.S.
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RU2196602C1 |
| (-)-4-AMINO-5-FLUORO-1-(2-HYDROXYMETHYL-1,3-OXATHIOLANE-5-YL)- -(1H)-PYRIMIDINE-2-ONE, A MIXTURE OF ITS ENANTIOMERS, METHODS OF THEIR SYNTHESIS, A METHOD OF TREATMENT |
1992 |
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RU2126405C1 |
| NUCLEOSIDES WITH ACTIVITY AGAINST HEPATITIS B VIRUS |
1999 |
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- Ehmbash Zhan-Lui
- Sommadossi Zhan-P'Er
- Skinazi Rehjmond F.
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RU2237479C2 |
| AGENT FOR INHIBITION OF REPRODUCTION OF ENVELOPED VIRUSES, METHOD FOR ITS PREPARING, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITION OF VIRAL INFECTIONS |
2003 |
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RU2236852C1 |
| METHOD OF PREPARING SODIUM 10-METHYLENE CARBOXYLATE-9-ACRIDONE OR 10- METHYLENECARBOXY-9-ACRIDONE FROM ACRIDONE |
1998 |
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RU2162843C2 |
| METHOD OF SYNTHESIS OF 2',3'-DIDEOXY-3'-THIACYTYDINE OR 2',3'- -DIDEOXY-3'-THIA-5-FLUOROCYTIDINE, NUCLEOSIDE ENRICHED WITH ENANTIOMER, METHOD OF SYNTHESIS OF 1,3-OXATHIOLANE, METHOD OF SYNTHESIS OF 2-ACYLOXY-5-ACYLOXY-1,3-OXATHIOLANE ENRICHED WITH ENANTIOMER, ENANTIOMERS, METHOD OF CLEAVAGE OF NUCLEOSIDE ENANTIOMERS |
1991 |
- Lajott Dennis Ts
- Choj Vu-Big
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RU2125558C1 |
