PROCESS FOR MANUFACTURE OF LONG-ACTING BRONCHOLITHIC MEDICINAL COMPOSITION BASED ON THEOPHYLLINE Russian patent published in 1995 - IPC

FIELD: medicine; pharmaceutical industry. SUBSTANCE: this process includes such steps as admixing of theophylline with interpolymer complex of polymethacrylic acid and polyethyleneglycol, wetting admixture by interpolymer complex solution in phosphate buffer, alcohol or water-alkali solution at pH value of 4.5 to 7.5, subjecting resulting stock to water-stream granulation, drying this stock, and finally carrying out subsequent steps of manufacture of finished medicinal form. According to another version, tablets may be manufactured by method of briquetting. Tablets are coated with film-forming solution based on same interpolymer complex. Medicinal preparation manufactured by disclosed method is effective when administered in dose of 450 to 600 mg/24 h and maintains therapeutic concentration of theophylline in plasma by two intakes. Mean absorption time is 12 h. EFFECT: more prolonged period of maintaining of effective concentration of medicinal preparation in blood. 3 cl, 3 tbl