PROCESS FOR MANUFACTURE OF LONG-ACTING QUINIDINE SULFATE TABLETS Russian patent published in 1995 - IPC

FIELD: medicine; pharmaceutical industry. SUBSTANCE: this process includes such steps as admixing quinidine sulfate with interpolymer complex of polymethacrylic acid and polyethyleneglycol, moistening resulting admixture with either water or interpolymer complex solution, adding sugar, subjecting resultant stock to water-stream granulation, drying stock, and then carrying out prescribed steps of manufacture of finished medicinal form. According to another version, tablets may be manufactured by method of briquetting. EFFECT: with equal maximum concentration of quinidine in blood, time required for attaining desired concentration, mean time needed to retain quinidine in organism, and duration of existence of effective concentration of quinidine are approximately two times as high; biological availability of disclosed long-acting quinidine sulfate tablets manufactured on basis of interpolymer complex is two to three times as high in comparison with "Quinelentin" tablets. 3 cl, 1 tbl