DERIVATIVES OF 1,8-BENZO-[B]-NAPHTHIRIDINE OR THEIR SALTS WITH METALS, NITROGEN BASES OR ACIDS, OR THEIR HYDRATES SHOWING ANTIBACTERIAL ACTIVITY Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of 1,8-benzo-[b] -naphthiridines of the formula (I) (image), where R₁ H, alkyl, hydroxyalkyl; R₂ H, alkyl, fluoroalkyl, cycloalkyl, alkyloxy, alkylamine; R₃ alkyl, H, cycloalkyl; R₄ and R₅ are different hydrogen or alkyl; R₆ H, F; n 1 or 2, or their salts or hydrates. Reagent 1: compound of the formula (II) (image). Reagent 2: compound of the formula (III) (image). Reaction conditions: in the presence of acceptor of organic or inorganic acid, in the medium of solvent. Synthesized compounds show antibacterial effect. EFFECT: improved method of synthesis.