FIELD: organic chemistry. SUBSTANCE: invention relates to method of synthesis of derivatives of benzo-[b]-naphthyridine of the general formula (I) where R means carboxyl, (C1-C4)-alkylhydroxycarbonyl, -CN, carbamoyl, (C1-C4)-alkylcarbamoyl and di-(C1-C4)-alkylcarbamoyl; R' - (C1-C4)-alkyl or (C3-C6)-cycloalkyl, and their salts. Method involves condensation of chlorofluoroquinoline derivative of the general formula (II) where R1 - (C1-C4)-alkyl with amine of the general formula (III): R'-NH-CH2-CH2-R'' where R'' - (C1-C4)-alkylhydroxycarbonyl, -CN, carbamoyl, (C1-C4)-alkylcarbamoyl and di-(C1-C4)-alkylcarbamoyl. The synthesized derivative of chlorofluoroquinoline is subjected for cyclization followed by oxidation of product and isolation of the end compound as free form or salt. Derivatives of benzo-[b]-naphthyridines of the general formula (I) where R - -CN, carbamoyl, (C1-C4)-alkylcarbamoyl and di-(C1-C4)-alkylcarbamoyl are new compounds. EFFECT: improved method of synthesis. 2 cl
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