PROCESS FOR PREPARING 1-BENZYL-3-HYDROXYMETHYLINDAZOLE ETHERS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF Russian patent published in 1995 - IPC

Abstract RU 2044729 C1

FIELD: chemical industry. SUBSTANCE: 1-benzyl-3-hydroxymethylindazole of the formula: A-CH2-O-CRR′-COOR′′′(1) (1) wherein A is 1-benzylindazol-3-yl; R,R′ are the same or different H or CH3; R″-H is H or a residue of saturated aliphatic C1-C3-alcohol, or pharmaceutically acceptable salts thereof, if R′′′-H is H. Reagent 1: a compound of the formula: A-CH2-OH. Reagent 2: an alkali metal or a derivative thereof. Reaction conditions: the alsoholate thus formed of the formula: A-CH2-OMe is treated with a compound of the formula: X-CRR′-COOR′′′ wherein X is halogen, followed optionally by hydrolysis of the compound 1 in which R′′′ is a residue of saturated aliphatic C1-C3-alcohol to obtain compound 1 in which R′′′-H is H and by conversion thereof into a salt. EFFECT: more efficient preparation process. 1 tbl

Similar patents RU2044729C1

Title Year Author Number
PROCESS FOR PREPARING 2-BENZYL-3-(3-DIMETHYLAMINO-PROPYLTHIO)-2H-INDASOLE 0
  • Bruno Silvestrini
  • Leandro Bajokki
SU1042614A3
ANTIBECHIC COMPOSITION CONTAINING ANTIBECHIC AGENT AND BENZIDAMINE 1995
  • Depal'Mo Galli Andzheli
RU2143901C1
BENZIDAMINE APPLICATION METHOD FOR TREATING PATHOLOGIC STATES INDUCED BY FUNCTIONAL METABOLISM DISORDERS 1994
  • Valerio Chioli
RU2160102C2
METHOD OF PREPARING PARA-ISOBUTYLHYDRATROPIC ACID 0
  • Leonardo Bajokki
SU720999A3
METHOD OF OBTAINING META-BENZOYLHYDRATROPIC ACID OR ITS SALT WITH SECONDARY AMINE 0
  • Leandro Bajokki
SU639441A3
(S) or (R) ENANTIOMERS, METHOD OF PREPARING THEREOF, AND INTERMEDIATE PRODUCT 1994
  • Leandro Bajokki
  • Valerio Chjoli
RU2128180C1
ALKYL DERIVATIVES OF TRAZODONE, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION 1993
  • Leandro Bajokki
RU2126801C1
N-PHENYLALKYL-SUBSTITUTED DERIVATIVES OF α-AMINOCARBOXAMIDE, METHOD OF THEIR SYNTHESIS, PHARMACOLOGICALLY ACTIVE COMPOSITION ON THEIR BASE AND A METHOD OF DISEASE DEVELOPMENT PROPHYLAXIS 1992
  • Filippe Dostert[Fr]
  • Paolo Pevarello[It]
  • Franko Khejdemperger[It]
  • Mario Varasi[It]
  • Al'Berto Bonsin'Ori[It]
  • Romeo Ronkuchchi[It]
RU2097371C1
OPIOID PEPTIDES AND PHARMACEUTICAL COMPOSITION 1995
  • Uill'Jam Braun
  • Dzhon Dimajo
  • Piter Shiller
  • Rene Martel'
RU2146681C1
ANTHRACYCLINE GLYCOSIDES AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, METHOD OF THEIR SYNTHESIS, DIIODOINTERMEDIATE COMPOUND AND METHOD OF ITS SYNTHESIS 1991
  • Al'Berto Bardzhotti[It]
  • Maria Grandi[It]
  • Antonio Suarato[It]
  • Daniehla Faiardi[It]
RU2100366C1

RU 2 044 729 C1

Authors

Bruno Silvestrini[It]

Leandro Bajokki[It]

Dates

1995-09-27Published

1991-06-05Filed