FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to alkyl derivatives of trazodone of the general formula (I) 
where only one of R, R', R' and R''' means C1-3-alkyl and others are hydrogen, and their salts with physiologically acceptable an inorganic or an organic acids. Compounds are synthesized by interaction of compound of the formula (III) 
or its alkaline metal salt with piperazine compound of the formula (II) 
where R, R', R'' and R''' have values as indicated in the formula (I) and X means chlorine or bromine at boiling point or reaction mass. Compounds of the formula (I) show decreased affinity to adrenergic receptors as compared with trazodone but exceeds trazodone with respect to value LD50. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 10 cl, 8 ex
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