FIELD: organic chemistry. SUBSTANCE: product:[R-([R-(R*,S*)])]-[[2-methyl-1-(1-oxopropoxy)propoxy] (4-pheny- lbutyl)-phosphinyl] acetic acid, empirical formula is C19H29O6P, yield is 44% Reagent 1 is C6H5-(CH2)4-P(O)(OH)-CH2C(O)OCH2C6H5. Reagent 2 is (CH3)2CH-CH(Cl)-OC(O)C2H5. Reaction conditions: in the medium of inert organic solvent at 40-138 C, in the presence of organic base 4-methylmorpholine followed by hydrogenization of product formed as a mixture of four isomers, separation of the end diastereoisomeric pair by extraction with methylisobutylketone and fraction crystallization. Synthesized product is used as semiproduct for synthesis of hypotensive agent. EFFECT: improved method of synthesis. 2 cl
