BIPHENYL-SUBSTITUTED DERIVATIVES OF QUINOLINE, A PHARMACEUTICAL COMPOSITION, A METHOD OF INHIBITION Russian patent published in 1998 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to quinoline derivatives of the formula (I) where each of atoms A, B, D or E is carbon or one of A, B, D or E is nitrogen; X is O; R₁ and R₂ are substituents at atoms A, B, D or E when A, B, D or E - carbon they mean H, alkyl, alkoxy, halogen or carboxy-group; R₃ is COOH, COOR⁷; R₄ is H, alkyl, C_3-7-cycloalkyl; R₅ is optionally oxygen atom; R₆ is H, 5-tetrazolyl; R₆ and R₈ - alkyl; R₉ is H or lower alkyl, or their pharmaceutically acceptable salts that inhibit effect of angiotensin-II and can be used at hypertension. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 41 cl, 37 ex