ADDUCTS OF OROTIC ACID WITH AMINO ACIDS OR AMINES SHOWING HEPATOPROTECTIVE EFFECT Russian patent published in 1995 - IPC

Abstract RU 2047606 C1

FIELD: organic chemistry. SUBSTANCE: product: adducts of orotic acid with amino acids or amines of the formula (I) where NH2R beta-alanine residues, w -aminoenanthic acid, isoleucine methyl ester, D-glutamic acid, glutamic acid amide, asparagine, L-lysine, furfurylamine, 2-(3,4-dihydroxyphenyl)-ethylamine, guanidine, D-(-)-threo-p-nitrophenyl-2-aminopropanediol-1,3. Reagent 1: orotic acid. Reagent 2: β-alanine. Reaction conditions: temperature is below 80 C, stirring, cooling and crystallization. The yield is 69% of theory. Synthesized compounds were used in medicine, chemistry and agriculture. EFFECT: improved method of synthesis. 1 tbl

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RU 2 047 606 C1

Authors

Burov Ju.V.

Radkevich L.A.

Pleshakov M.G.

Snegotskij V.I.

Shamshina E.N.

Ostapchuk N.V.

Pyn'Ko N.Eh.

Dates

1995-11-10Published

1993-06-18Filed