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2 084 449

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Application

94007788/04, 1994-03-02

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Actual filing date

1994-03-02

(45)

Published

1997-07-20

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Inventor

Burov Ju.V.Druzhinina V.V.Zhestkov V.P.Portnov Ju.N.Pyn'Ko N.Eh.Ostapchuk N.V.Radkevich L.A.Smirnov L.D.

(73)

Holder

Vserossijskij Nauchnyj Tsentr Po Bezopasnosti Biologicheski Aktivnykh Veshchestv

1-BENZYL-2-OXOTRYPTAMINE HYDROCHLORIDE AND ITS DERIVATIVES SHOWING HEPATOPROTECTIVE ACTIVITY Russian patent published in 1997 - IPC

Abstract RU 2084449 C1

FIELD: organic chemistry, amino acid derivatives. SUBSTANCE: product: 1-benzyl-2-oxotryptamine hydrochloride and its derivatives of the formula (I) at the corresponding radical values that show hepatoprotective activity. Empirical formulas are: C17H18N20 x HCl, C18H2N20 x HCl, C20H22N20 x HCl, C21H24N20 x HCl, C21H24N20 x HCl, and C23H26N20 x HCl. Reagent 1: N-arylaminopyrrolidone-2. Reagent 2: POCl2. Reaction conditions: in dioxane medium followed by hydrolysis. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 3 tbl

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RU 2 084 449 C1

Authors

Burov Ju.V.

Druzhinina V.V.

Zhestkov V.P.

Portnov Ju.N.

Pyn'Ko N.Eh.

Ostapchuk N.V.

Radkevich L.A.

Smirnov L.D.

Dates

1997-07-20—Published

1994-03-02—Filed

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