FIELD: as drug. SUBSTANCE: the product: 2,6-dimethyl-3- 5-di(carbomethoxy-4-(2-nitrophenyl)-1,4-dihydropyridine; the yield about 80%, mp 172 C. Reagent 1: 2- nitrobenzaldehyde. Reagent 2 acetoacetic methyl ester. Reagent 3: ammonia. Reaction conditions: at 76-81 C for 5-8 hr in lower alkyl alcohol at molar ratio of components of 1:(2.5-3.2):(3.4-3.9), respectively. The recovery of the desired product and purificaiton are carried out when illuminated with red light source. EFFECT: more efficient preparation.
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING DIMETHYL ESTER OF 2,6-DIMETHYL-4-(2-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID (NIFEDIPINE) | 2019 |
|
RU2723630C1 |
| PROCESS FOR PREPARING 4-(2-NITROPHENYL)-2,6-DIMETHYL-3,5-DICARBOMETHOXY-1,4-DIHYDROPYRIDINE | 0 |
|
SU1099842A3 |
| PROCESS FOR PREPARING 2-OXY-4- (METH)ACRYLOYLOXYBENZOPHENONE | 1992 |
|
RU2034827C1 |
| ETHYL AND 3-(N,N-DIMETHYLAMINO)-2,2-DIMETHYPROPYL DIESTER OF 2,5-DIMETHYL-4-(3-NITROPHENYL)-1,4- DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID HYDROCHLORIDE SHOWING PROLONGED ANTIHYPERTENSION EFFECT | 1991 |
|
RU2043341C1 |
| 0 |
|
SU513620A3 | |
| 0 |
|
SU515452A3 | |
| 0 |
|
SU518127A3 | |
| 0 |
|
SU365069A1 | |
| METHOD OF SYNTHESIS OF 2-METHOXY-5-CHLOROBENZOIC ACID | 1992 |
|
RU2030387C1 |
| METHOD FOR SYNTHESIS OF 1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-PYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER | 0 |
|
SU1766254A3 |
