FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to a method of producing dimethyl ester of 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid (nifedipine) of formula (1) by heating 2-nitrobenzaldehyde with methyl ether of acetoacetic acid and aqueous ammonia without solvent, characterized in that the reaction is carried out in the presence of aerosil (commercially available nano-sized silicon oxide) at 45–50 °C for 5–5.5 hours, ratio of 2-nitrobenzaldehyde, methyl ether of acetoacetic acid and ammonia is 1:2:2.4, purification of the end product is carried out together with a step for separating the catalyst from hot methanol or ethanol.
EFFECT: one-step method of producing nifedipine using an available heterogeneous catalyst, characterized by high output of the end product.
1 cl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROCESS FOR PREPARING 2,6-DIMETHYL-3,5-DI(CARBOMETHOXY)- 4-(2-NITROPHENYL)-1,4-DEHYDROPYRIDINE (NIPHEDIPINE) | 1992 |
|
RU2057122C1 |
| PROCESS FOR PREPARING 4-(2-NITROPHENYL)-2,6-DIMETHYL-3,5-DICARBOMETHOXY-1,4-DIHYDROPYRIDINE | 0 |
|
SU1099842A3 |
| ETHYL AND 3-(N,N-DIMETHYLAMINO)-2,2-DIMETHYPROPYL DIESTER OF 2,5-DIMETHYL-4-(3-NITROPHENYL)-1,4- DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID HYDROCHLORIDE SHOWING PROLONGED ANTIHYPERTENSION EFFECT | 1991 |
|
RU2043341C1 |
| DERIVATIVES OF 1,4-DIHYDROPYRIDINE AND PHARMACEUTICAL COMPOSITION ON THEIR BASE, POSSESSING VASOACTIVE ACTION | 1991 |
|
RU2081869C1 |
| METHOD OF PREPARING DIHYDROPYRIDINE DERIVATIVES | 0 |
|
SU1831476A3 |
| 0 |
|
SU518127A3 | |
| METHOD OF PREPARING 3-ETHYL-5-METHYL ESTER OF 2-[2-N-(PHTHALIMIDO)ETHOXYMETHYL]- 4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID | 1999 |
|
RU2161156C1 |
| 0 |
|
SU379091A1 | |
| METHOD OF PRODUCING 1,4-DIHYDROPYRIDINES OR HYDROCHLORIDES THEREOF | 0 |
|
SU1279528A3 |
| METHOD OF SYNTHESIS OF 3-ETHYL-5-METHYL-2-(2-AMINOETHOXYMETHYL)- -4-(2-CHLOROPHENYL)-6-METHYL-1,4-DIHYDRO-3,5-PYRIDINE DICARBO-XYLATE AND BENZENESULFOACID SALT (AMLODIPINE BEZYLATE) | 1998 |
|
RU2163597C2 |
