FIELD: pharmacology. SUBSTANCE: octahydrobenz (d) quinolines of formula 1 are prepared by reacting compound of formula 2 with strong base, e.g.p. butyllithium, the resulting anion 2a is reacted with trealkylsilylhalide and the resulting keteneacetal 2b is reacted with proton source, e.g. hydrochloric acid. Structure of compound of formulae 1, 2, 2a and 2b: 
EFFECT: more efficient preparation process.
| Title |
Year |
Author |
Number |
| BENZO(G)QUINOLINE DERIVATIVES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, AND METHOD OF TREATMENT |
1996 |
- Nojmann Peter
- Pfeffli Paul'
- Zajler Maks Peter
- Svoboda Robert
|
RU2158738C2 |
| METHOD OF SYNTHESIS OF SUBSTITUTED PHTHALIDES OR HETEROCYCLIC PHTHALIDES |
1991 |
- Richard Dzhejms Anderson[Us]
- Jan Stjuart Klaudzdejl[Gb]
- Takeo Khokama[Us]
|
RU2040522C1 |
| PROCES FOR PRODUCING DERIVATIVES OF 2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE OR THEIR SALTS |
0 |
- Yanosh Pless
- Maks-Peter Zajler
|
SU927110A3 |
| BENZO[F]QUINOLINONE, METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1995 |
- Dzhejms Ehdmund Audia
- Kevin Li Khehl
- Tomas Dzhozef Kress
- Loretta Ehjms Makkvejd
- Blehjk Li N'Jubauehr
- Vinsent Patrik Rokko
- Dzhejms Patrik Vepsik
|
RU2172312C2 |
| BENZO-[F]-QUINOLINONES, METHOD OF INHIBITION, METHOD OF SYNTHESIS OF BENZO-[F]-QUINOLINONES, METHOD OF RACEMATES SPLITTING AND DI-P-TOLUOYL-(D)- OR (L)-TARTARIC ACID SALT |
1992 |
- Dzhejms Ehdmund Odia
- Kennet Stiven Kherch
- Charl'Z Dehvid Dzhons
- Dehvid Ehrnst Lokhorn
- Loretta Ehms Makkuajd
|
RU2126386C1 |
| AMINOGUAMIDINES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION BASED THEREON |
1992 |
- Rudol'F Karl Andreas Giger[Ch]
- Anri Matt[Fr]
|
RU2095347C1 |
| METHOD OF OBTAINING HETEROGENOUS RING COMPOUNDS OR SALTS THEREOF |
0 |
|
SU613721A3 |
|
0 |
- Robert V.Kumbs
- Evgen E.Gelenti
|
SU493962A3 |
| METHOD OF PREPARING ISOQUINOLINE DERIVATIVES OF THEIR SALTS |
0 |
|
SU852172A3 |
|
0 |
- Villiem Dzh.Khoulikhen
- Dzheffri Nejdelson
|
SU493964A3 |
