AMINOGUAMIDINES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION BASED THEREON Russian patent published in 1997 - IPC

FIELD: medicine. SUBSTANCE: present invention describes compounds of formula: A-X--Y-NH-B wherein A is optionally substituted benzothiophene, indole, 4-aza-and 7- azabenzothiophene or indole; in position 5 A is hydrogen, halogen, optionally substituted alkyl, hydroxy, nitro, amino, alkylamino, acylamino, alkoxycarbonyl, sulphamoyl, cyano, trimethylsilyl, carboxy, carbamoyl, phosphate, oxycarbamoyl, heterocyclic radical or ether or ester group; X--Y is -CR₈-N= or CH(R₈)-NH in which R₈ is H or alkyl and is attached to A in position 3, and B is heterocyclic radical or residue or formula: wherein R₁₀ is optionally substituted alkyl, cycloalkyl, aryl, adamantyl, acyl or carbamoyl, and X is alkylthio or NR₃R₁₀ in which R₃ is H or alkyl, or R₃ and R₁₀ together with nitrogen atom to which they are attached form heterocyclic radical in free form or as salt. Said compounds have pharmaceutical activity for treating gastrointestinal tract disorders. EFFECT: improved properties of the pharmaceutical composition. 11 cl, 5 tbl