BENZO-[F]-QUINOLINONES, METHOD OF INHIBITION, METHOD OF SYNTHESIS OF BENZO-[F]-QUINOLINONES, METHOD OF RACEMATES SPLITTING AND DI-P-TOLUOYL-(D)- OR (L)-TARTARIC ACID SALT Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to benzo-[a] -quinolinone of the formula (I) where R is H, alkyl or phenalkyl; Z and Z' - are H, alkyl or one of Z and Z' with R⁵ forms a bond carbon-carbon Y is H or methyl or with SSS forms a band carbon-carbon; R¹ is H or forms a bond carbon-carbon with one of Y or R³; R² is H or C_1-4 alkyl; R³ is H or R¹ forms a bond carbon-carbon; R⁴ is H or with R⁵ forms a bond carbon-carbon; R⁵ is H or with one of Z or Z' forms a bond carbon-carbon; n = 1 or 2; X is H, halogen, NO₂, cyano-group, CF₃, C_1-6-alkyl, alkoxy-, carboxy-, alkoxycarbonyl-, amino-, amido-group or a group -A-O-R⁶ where A is C_1-6-alkylene, C_2-6-alkenyl or C_2-6-alkynylene; R⁶ - halogen, hydroxy, alkylamido-group or its pharmaceutically acceptable salt. Compounds of the formula (I) are selective steroid inhibitors of 5α--reductase showing strong effect and can be used for treatment of patients with prostate benignity tumors, alopecia, acnes and seborrhea in males. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 19 cl, 1 tbl, 69 ex