ENANTIOSELECTIVE METHOD OF SYNTHESIS OF S-ENANTIOMER OF OPTICALLY ACTIVE ALIPHATIC OR AROMATIC CYANOHYDRIN Russian patent published in 1996 - IPC

Abstract RU 2067089 C1

FIELD: organic chemistry, biotechnology. SUBSTANCE: product: S-enantiomer of optically active cyanohydrin. Reagent 1: corresponding aldehyde or methylketone. Reagent 2: cyano-group donor - R₁R₂C(OH)(CN), where R₁, R₂ - alkyl. Reaction conditions: enzyme S-hydroxynitrillyase at activity at least 500 U, preferably, 500-2000 U, diluting agent, preferably, aqueous one. Donor: acetonecyanohydrin and S-hydroxynitrillyase from genus Hevea Brasiliensis or Sorghum bicolor are preferable. Isolation and purification is carried out by chromatography. Obtained product is used for synthesis bioactive substances (vitamins, pyrethroids, etc.). EFFECT: improved method of synthesis. 5 cl

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RU 2 067 089 C1

Authors

Kherfrid Gringl'[At]

Norbert Klempir[At]

Peter Pekhlauer[At]

Dates

1996-09-27—Published

1992-10-26—Filed