METHOD OF SOLID PHARMACEUTICAL COMPOSITION MAKING Russian patent published in 1997 - IPC

FIELD: pharmacy. SUBSTANCE: method of preparing solid pharmaceutical compositions containing L-3,4-dihydroxyphenylalanine and L-α-hydrazino-a-methyl-3,4-dihydroxyphenylpropionic acid at their mass ratio = (3.5-10):1, respectively, involves the following stages: the indicated active components were milled with lactose and/or microcrystalline cellulose taken at amount 20-33% of composition mass and mixed if necessary with dyeing agent. The obtained mixture is treated with stearin at amount 1.5-2% of composition mass dissolved in aliphatic alcohol containing 2-4 carbon atoms, dried, granulated and then dried granulate is mixed if necessary with special additions and pressed to make tablets. The latter have 55-70% active components by mass. Also, film coating can be applied on tablet surface. EFFECT: improved method of composition making. 2 cl, 1 tbl