STRAIN OF BACTERIUM NEISSERIA MENINGITIDIS SEROGROUP A USED FOR MENINGOCOCCUM ADHESIVE PREPARING Russian patent published in 1997 - IPC

FIELD: microbiology. SUBSTANCE: strain Neisseria meningitidis 356/4 (Collection GISK N 224) is selected from the strain N. meningitidis 356 (GISK) isolated from the patient cerebrospinal fluid followed by cloning and selection of variant exhibiting high and stable adhesive activity. Strain is gram-negative and 40% microbe cells form fimbrias. On the solid nutrient medium with 2% Hottinger agar with addition of 20% inactivated equine serum and 0.5% glucose the yield of biomass is 12 billion/ml for 18-20 h culturing. Strain ferments glucose and maltose with acid formation but does not ferment sucrose, levulose and lactose. Strain belongs to serogroup A, sticks to human erythrocytes and epitheliocytes of mucous. Adhesion index is 56 ± 17. EFFECT: bacterial strain indicated above. 2 tbl